What does dissociation feel like during ketamine infusions?

If you’re considering ketamine therapy for depression, PTSD, or anxiety, you’ve probably heard the word “dissociation.” It’s one of the most common experiences during a ketamine infusion and one of the most frequently asked questions I receive as a provider—but what does dissociation actually feel like?

In this post, we’ll explore what dissociation is, why it happens during ketamine treatment, and what you can expect during your infusion at Mosaic Infusions & Wellness.

What Is Dissociation?

Dissociation is a temporary shift in how your brain processes reality. During a ketamine infusion, it can feel like you’re floating outside your body, disconnected from your usual thoughts or emotions—but in a surprisingly peaceful or even insightful way.

This state is a normal and expected part of the ketamine experience. It’s not dangerous, and it wears off shortly after your infusion ends.

What Does Dissociation Feel Like?

Every person experiences dissociation differently, but here are some common descriptions from patients:

• “I felt like I was watching myself from outside my body.”

• “Time didn’t exist—everything slowed down or sped up.”

• “My thoughts became very clear, almost like I could step back and see them.”

• “I felt emotionally safe, even when thinking about hard things.”

• “It was like a dream, but I knew I was awake.”

Some people report visual imagery, deep introspection, or a profound sense of calm. Others may feel a little strange or confused during the session, but almost always describe feeling better afterward.

Is Dissociation Uncomfortable or Scary?

For most people, dissociation is not scary—it’s unfamiliar at first, but not unpleasant.

At Mosaic Infusions & Wellness, we create a calm, supportive environment to help you feel safe during your infusion. Your care team will monitor your response and guide you through the experience.

If at any point you feel overwhelmed or uncomfortable, we can adjust your dosage or offer grounding techniques. Please don't hesitate to let us know how you are feeling before, during, or after an infusion.

Why Does Ketamine Cause Dissociation?

Ketamine works differently than traditional antidepressants. It acts on a neurotransmitter called glutamate, and temporarily disrupts certain brain pathways. This disruption creates the dissociative state—but it also helps “reset” unhealthy patterns related to depression and anxiety.

In fact, researchers believe that dissociation may be linked to how ketamine creates fast, lasting improvements in mood.

What Happens After the Infusion?

The dissociation fades within 30–60 minutes after your infusion ends. Most patients leave feeling calm, clear, and emotionally lighter.

Some people even gain new perspectives on their thoughts or experiences during the session—insights they carry into therapy or daily life. We encourage patients to meet regularly with their therapist or counselor while undergoing ketamine infusions to amplify the effects of the infusion.

Final Thoughts

Dissociation during ketamine therapy can sound strange, but for many, it’s a meaningful part of the healing process. At Mosaic Infusions & Wellness, we walk with you through every step, making sure you feel informed, supported, and safe.

If you’re curious about ketamine therapy or wondering if it’s right for you, click the button below to reach out to us.

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